The Istituto di Neuroscienze

The Istituto di Neuroscienze was founded in 1989 by Dr. Stefano Pallanti to translate the latest neuroscientific evidence into diagnosis and treatment.

The Institute offers innovations based on validated clinical evidence that will give patients, families, and their treating physicians a concept to share and refer to in the care process.

We know that it takes about 17 years for Administrative Agencies such as the Food and Drug Administration (FDA) to include, in their guidelines, a new medicine or a new technology after the science co-validates their effectiveness (Harvard Business Review).

During this long period of time, scientific research produces new advances daily: consequently, a large gap arises between approved treatments and those not yet approved but scientifically tested and proven as effective and valid (off-label treatments).

“Off-label" indicates the use of a drug or medical device for a protocol not officially included in the guidelines and not described on the instruction sheet. What does this really mean?

Find out what it means

Dr. Pallanti of the Istituto di Neuroscienze acquires research concepts every day and, if the clinical picture requires it, he proposes evidence-based off-label treatments in accordance with the latest international scientific evidence.

Therefore, these are not experimental treatments but treatments that have been tested and chosen only because they prove the most suitable for that specific person.

The mission of the Istituto di Neuroscienze means to offer treatments by translating all the latest neuroscientific evidence into therapeutic principles.

Only in research contexts, such as the Istituto di Neuroscienze, where you have an open and participatory mentality, is it possible to propose the latest concepts of neuroscience (evidence-based-treatment).

Learn more about Dr. Pallanti's Method and discover how it translates into personalized and functional treatment plans for each individual case.

Explore the Pallanti Method

Services

For Persons:

• Specialized and Neuroscientific Psychiatry;

• Precise Diagnosis;

• Personalized care based on neuroscientific evidence.

For Companies:

• Clinical studies and scientific research;

• Development of the precision diagnosis program for hospitals and nursing homes;

• Development of cutting-edge care projects and programs for hospitals and nursing homes;

• Development of product growth strategies for pharmaceutical and biotech companies;

• Sports neuroscience: development of strategies and technical support to improve performance and to prevent brain damage for sports teams and clubs;

• Development of stress prevention and suicide prevention programs within hospitals, nursing homes, schools, and companies.

Training Courses:

• For Health Care Providers: the notions useful for providing a TMS service for substance and behavioral addictions;

• Internship;

• Conferences;

• CME courses.

SERVICES OF THE ISTITUTO DI NEUROSCIENZE

Remote visits via Skype

Dr. Stefano Pallanti is a pioneer in telemedicine, recognizing the potential of this remote visiting modality since 2008. Since then, more than 1,500 patients from all over Italy and Abroad have been making remote visits via Skype with Dr. Pallanti and his collaborators of the Istituto di Neuroscienze, to benefit from our experience regardless of their geographical location!

Choose specialized visits via Skype with Dr. Pallanti and start your healing journey, wherever you are!

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Therapy Resources

Neuromodulation Therapy

• rTMS (Transcranial Magnetic Stimulation);

• Theta-Burst TMS;

• Theta-Burst Multi Session Treatment (SNT);

• Deep TMS;

• tDCS (Transcranial Direct Current Stimulation);

• Photo-Bio-Modulation;

• Neurofeedback;

• Vagus Nerve Stimulation;

• Light Therapy;

• PESF.

IV Therapy (Terapia endovenosa infusionale)

• Ketamine;

• Citalopram;

• Clomipramine;

• Ademetionine;

• N-Acetylcisteyne;

• Sodium Valproate;

• Levosulpiride;

• Tiapride;

• Secretine.

Spray

• Oxytocin

• Esketamine

Pharmacological Therapy

Psychotherapy – CBT – EMDR

Pharma-standard Supplements

Mindfulness

Precise Diagnostic of the II and III level

Throughout medicine, different and progressive levels of specialist care receive definition, but in the field of psychiatry these concepts still find little application.

Therefore, definition of the “personalized diagnosis” provides the first step of this evolution.

Symptoms are not in themselves the diagnosis, and the goals of treatment must be shared and directed at the causes of the disorder.

Psychiatry requires moving from studying traditionally classified diagnoses to understanding the constructs and mechanisms involving certain brain circuits specifically defined for each maladaptive behavior (Cuthbert & Insel, 2013; Insel et al., 2010).

In fact, in addition to the clinical definition of any disorder, physicians must necessarily define its specifiers, the characteristics of the course (etiology), the neuro-functional correlates, with particular attention to cognitive functioning and the inflammatory response.

All these factors cannot be accounted for in the interview alone but require the use of psychometric tools which can be followed by functional assessments.

This first step takes us from General Psychiatry to Specialist Psychiatry, or the second level, and then to the Neuroscientific, or the third level.

The Istituto di Neuroscienze offers precision diagnosis through level II and III tools:

Personalized Multimodal Care

• Person centered beyond behavior, based on Individualized Diagnosis

• The latest neuroscientific evidence-based treatment

• Integration of all useful treatments

Person centered

The treatment option aims to modify the functional level of a person as a whole and not merely that person’s behavior. Therapies differ, depending on the contextual moment of life. Dr. Pallanti designs the most suitable treatment for each person based on precision psychiatry.

The latest neuroscientific evidence-based treatment

Dr. Pallanti of the Istituto di Neuroscienze acquires research concepts every day and, if the clinical picture requires it, he proposes evidence-based off-label treatments in accordance with the latest international scientific evidence. These are not experimental treatments but treatments that have been tested and chosen only because they prove the most suitable for that specific person.

Integration of all useful treatments

The reduction to a single therapeutic technique is overcome by the Pallanti Method's approach, which combines Multidisciplinary and Multimodal treatments suitable for everyone: Neuromodulation Therapy, Pharmacological Therapy, Psychotherapies, Pharma-Standard Supplements, Natural Cures, Mindfulness, and anything else that has been scientifically documented effective. The approach constitutes, therefore, an interdisciplinary method to allow the use of every therapeutic resource useful for a specific person. The treatment becomes highly personalized after specialized evaluations, considered individually, case by case.

This new culture overpowers any potential conflict between medicines, technological therapies, and psychotherapy. In science, this conflict does not exist. The Pallanti Method therefore uses all useful treatments for patients who refer to the Istituto di Neuroscienze.

Our Treatment Plans

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ADHD

What is Attention Deficit/Hyperactivity Disorder (ADHD) and what are the most common symptoms? Find out on this dedicated page.

The Istituto di Neuroscienze is a center of excellence for the diagnosis and treatment of Life-Span ADHD that includes preschool children through adults.

Discover more

Anxiety and Anxiety Disorders

Dr. Stefano Pallanti is an Expert in Anxiety for the World Health Organization and one of the world's earliest pioneers ― since 2005 ― in the use of Neuromodulation Therapies for the treatment of Anxiety Disorders.

The Istituto di Neuroscienze offers the most advanced and innovative therapeutic options for the treatment of these disorders.

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Depression

Treatment for Depression integrates many different skills and must be carried out by specially trained specialists. The treatments generally offered often do not work because the specific subtype of depression and other comorbid disorders are not considered.

At the Istituto di Neuroscienze, we offer person-centered treatment for depression based on individualized diagnosis and integrated with natural cures.

Discover more

OCD and Obsessive-Compulsive Spectrum Disorders

Dr. Pallanti is one of the leading experts on Obsessive-Compulsive Disorder in the world.

The Istituto di Neuroscienze integrates a variety of treatment methods that have proven successful in treating Obsessive-Compulsive Spectrum Disorders: Neuromodulation Therapies, Pharmacological Therapies, Psychotherapy and Natural Therapies.

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Autism

Autism is not a disease in itself, but is a condition of Neuro-immune diversity that can become dysfunctional in relation to pervasiveness, severity, and environmental response. Therefore, it is possible to treat dysfunctions but not cure them.

It is difficult to generalize about therapies, and each therapy must be evaluated individually.

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Gambling Disorder

Still too few people know about the risks related to Gambling and even fewer know that Gambling Disorder can be treated.

At the Istituto di Neuroscienze, we offer personalized treatment programs that integrate Psychological Support, Pharmacological Therapy and Neuromodulation Therapies.

Discover more

Therapeutic Programs

• Children and Adult ADHD

• Children and Adult Autism

• Treatment resistant Bipolar Depression

• OCD Spectrum

• PANDAS and behavioral immunology

• Behavioral Addiction

• Alcohol, Cocaine, Tabacco and Painkillers Addiction

• Fibromyalgia and Neuropathic Pain

• Reproductive Psychiatry

• Obesity and Bulimia

• Mild Cognitive Impairment

• Traumatic Brain Disorders

• Parkinson

• Interventional Psychiatry

• Sports Neuroscience and Performance

Combination Therapy

• TMS with EMRD and Mindfulness

• Deep TMS with CBT

• Use of Pharma-standard antioxidants and Probiotics to regulate the inflammation and the neuroplasticity in Autism and ADHD

• Neuromodulation with neuropharmacology

Neuromodulation Therapies

Non-pharmacological, non-invasive, and free of side effects.

• Promote neurogenesis

• Anti-inflammatory

• Improve cognitive abilities

• Facilitate new skills learning

• Repair and restore vascular damage of the brain

La terapia di Neuromodulazione è un insieme di tecniche diagnostiche e terapeutiche che utilizzano stimoli fisici, magnetici, elettrici e luminosi che agiscono promuovendo la Neurogenesi, ovvero il processo di formazione di nuove cellule nervose e in alcuni casi promuovono anche la reazione antiinfiammatoria e cicatriziale delle cellule gliali di sostegno.

Neuromodulation therapies use physical, magnetic, electrical and light stimuli that act by promoting Neurogenesis, or the process of formation of new nerve cells (neurons), increasing the neuronal plasticity and the creation of new connections (synapses) between them. In some cases, they also promote the anti-inflammatory and anti-scarring reaction of the supporting glial cells.

Neuromodulation Therapies include:

― Repetitive Transcranial Magnetic Stimulation (rTMS);

― Transcranial Magnetic Stimulation Theta-Burst (TBS);

― Deep Transcranial Magnetic Stimulation (Deep TMS);

― Transcranial Direct Current Stimulation (tDCS);

― Photo-Bio-Modulation (PBM);

― Neurofeedback;

― Vagus Nerve Stimulation (VNS);

― Light Therapy;

― Pulsating Electrostatic Field Therapy (PESF).

Neuromodulation Therapies represent a significant advance in the direction of Personalised Care.

Discover the neuromodulation therapies

Therapeutic areas of Neuromodulation Therapies

Neuromodulation Therapies offered by the Istituto di Neuroscienze can be applied effectively ― as off-label but scientifically validated therapies ― in a broad spectrum of neuropsychiatric areas and on different types of patients:

In Psychiatry:

― Drug-Resistant patients;

― Patients with residual symptoms;

― Patients with cognitive symptoms;

― ECT candidates or ECT resistant patients;

― Patients with Mood Disorders (Depression, Bipolar Disorder);

― Reproductive Psychiatry patients (pregnant women);

― Post-partum Depression;

― Patients undergoing assisted fertilization;

― Depression associated with metabolic disorders;

― Depression for cases where medications should be avoided (liver / kidney failure);

― Seasonal Depression;

― Autism - reduction of repetitive behaviors and improvement of communication;

― Psychosis - reduction of hallucinations, reduction of negative symptoms;

― Obsessive Compulsive Disorder and OCD Spectrum Disorders (Trichotillomania, Tics);

― Behavioral addictions (Gambling, Internet, Pornography);

― Substance Use Disorders (Cocaine, Alcohol, THC);

― Diabetes.

In Neurology:

― Cognitive rehabilitation;

― Post-stroke rehabilitation or head trauma;

― Pain, including headaches and fibromyalgia;

― Parkinson's Disease;

― Tinnitus (Tinnitus).

― Insomnia.

In Weight and Nutrition Disorders:

― Carbohydrate Craving;

― Obesity and Binge Eating;

― Eating Disorders.

The Istituto di Neuroscienze's professional Team assists thousands of patients each year through personalized care pathways.

Discover the team

Customized and Innovative Treatment Solutions

Precision Diagnosis for Personalized Care

• Genetics of drug response;

• Neurophysiological evaluation;

• Multidisciplinary evaluation with Immunologist, Neurologist, Rheumatologist and other specialists, depending on the cases.

Integral Medicine

• Neuromodulation Therapy, Pharmacological Therapy, Psychotherapies, Pharma-Standard Supplements, Natural Cures, Mindfulness, and anything else that has been scientifically documented effective.

International Network

• The possibility of consulting international experts, thanks to the collaboration with the most important specialized centers in the world.

Tele Medicine: remote psychiatric visits and psychotherapy

• For continuity and shortening distances: Specialist visits and psychotherapies in tele-medicine with psychometric evaluation.

Support to patients and family

• Rehabilitation and skills development program for patients with ADHD and Learning Disability.

Health Authorization in the following areas: Psychiatry, Child Neuropsychiatry, Neurophysiopathology Psychology and Psychotherapy.