The Istituto di Neuroscienze was founded in 1989 by Dr. Stefano Pallanti to translate the latest neuroscientific evidence into diagnosis and treatment.
The Institute offers innovations based on validated clinical evidence that will give patients, families, and their treating physicians a concept to share and refer to in the care process.
We know that it takes about 17 years for Administrative Agencies such as the Food and Drug Administration (FDA) to include, in their guidelines, a new medicine or a new technology after the science co-validates their effectiveness (Harvard Business Review).
During this long period of time, scientific research produces new advances daily: consequently, a large gap arises between approved treatments and those not yet approved but scientifically tested and proven as effective and valid (off-label treatments).
“Off-label" indicates the use of a drug or medical device for a protocol not officially included in the guidelines and not described on the instruction sheet. What does this really mean?
Dr. Pallanti of the Istituto di Neuroscienze acquires research concepts every day and, if the clinical picture requires it, he proposes evidence-based off-label treatments in accordance with the latest international scientific evidence.
Therefore, these are not experimental treatments but treatments that have been tested and chosen only because they prove the most suitable for that specific person.
The mission of the Istituto di Neuroscienze means to offer treatments by translating all the latest neuroscientific evidence into therapeutic principles.
Only in research contexts, such as the Istituto di Neuroscienze, where you have an open and participatory mentality, is it possible to propose the latest concepts of neuroscience (evidence-based-treatment).
Learn more about Dr. Pallanti's Method and discover how it translates into personalized and functional treatment plans for each individual case.
Specialized and Neuroscientific Psychiatry;
Personalized care based on neuroscientific evidence.
Clinical studies and scientific research;
Development of the precision diagnosis program for hospitals and nursing homes;
Development of cutting-edge care projects and programs for hospitals and nursing homes;
Development of product growth strategies for pharmaceutical and biotech companies;
Sports neuroscience: development of strategies and technical support to improve performance and to prevent brain damage for sports teams and clubs;
Development of stress prevention and suicide prevention programs within hospitals, nursing homes, schools, and companies.
For Health Care Providers: the notions useful for providing a TMS service for substance and behavioral addictions;
Remote visits via Skype
rTMS (Transcranial Magnetic Stimulation);
Theta-Burst Multi Session Treatment (SNT);
tDCS (Transcranial Direct Current Stimulation);
Vagus Nerve Stimulation;
IV Therapy (Terapia endovenosa infusionale)
Psychotherapy – CBT – EMDR
Precise Diagnostic of the II and III level
Throughout medicine, different and progressive levels of specialist care receive definition, but in the field of psychiatry these concepts still find little application.
Therefore, definition of the “personalized diagnosis” provides the first step of this evolution.
Symptoms are not in themselves the diagnosis, and the goals of treatment must be shared and directed at the causes of the disorder.
Psychiatry requires moving from studying traditionally classified diagnoses to understanding the constructs and mechanisms involving certain brain circuits specifically defined for each maladaptive behavior (Cuthbert & Insel, 2013; Insel et al., 2010).
In fact, in addition to the clinical definition of any disorder, physicians must necessarily define its specifiers, the characteristics of the course (etiology), the neuro-functional correlates, with particular attention to cognitive functioning and the inflammatory response.
All these factors cannot be accounted for in the interview alone but require the use of psychometric tools which can be followed by functional assessments.
This first step takes us from General Psychiatry to Specialist Psychiatry, or the second level, and then to the Neuroscientific, or the third level.
The Istituto di Neuroscienze offers precision diagnosis through level II and III tools:
I Level: General Psychiatry
― Clinical interview
II Level: Specialized Psychiatry
― Subtype diagnosis;
― Definition of specifiers;
― An objective gravity measurement;
― Attribution of a degree of resistance;
― Evaluation of comorbidities;
― Psychodiagnostic evaluations;
― Psychometric assessments
― Neurofunctional evaluations;
― Assessments of cognitive functions;
― Rating scale for the quantification of symptoms;
― Multidisciplinary evaluation with an Immunologist, Neurologist, Rheumatologist and other specialists, depending on the specific case.
III Level: Neuroscientific Psychiatry
― Metabolic and immunological evaluations;
― Inflammation ratings;
― EEG, ECG, P300, PET, MRI;
― Blood tests;
― Plasma level tests;
― Genetic tests for pharmacological response;
― Challenge test for verifying the tolerability of medicine;
― Study of Sleep Habits.
Cura personalizzata Multimodale
Person centered beyond behavior, based on Individualized Diagnosis
The latest neuroscientific evidence-based treatment
Integration of all useful treatments
The treatment option aims to modify the functional level of a person as a whole and not merely that person’s behavior. Therapies differ, depending on the contextual moment of life. Dr. Pallanti designs the most suitable treatment for each person based on precision psychiatry.
The latest neuroscientific evidence-based treatment
Dr. Pallanti of the Istituto di Neuroscienze acquires research concepts every day and, if the clinical picture requires it, he proposes evidence-based off-label treatments in accordance with the latest international scientific evidence. These are not experimental treatments but treatments that have been tested and chosen only because they prove the most suitable for that specific person.
Integration of all useful treatments
The reduction to a single therapeutic technique is overcome by the Pallanti Method's approach, which combines Multidisciplinary and Multimodal treatments suitable for everyone: Neuromodulation Therapy, Pharmacological Therapy, Psychotherapies, Pharma-Standard Supplements, Natural Cures, Mindfulness, and anything else that has been scientifically documented effective. The approach constitutes, therefore, an interdisciplinary method to allow the use of every therapeutic resource useful for a specific person. The treatment becomes highly personalized after specialized evaluations, considered individually, case by case.
This new culture overpowers any potential conflict between medicines, technological therapies, and psychotherapy. In science, this conflict does not exist. The Pallanti Method therefore uses all useful treatments for patients who refer to the Istituto di Neuroscienze.
Our Treatment Plans
What is Attention Deficit/Hyperactivity Disorder (ADHD) and what are the most common symptoms? Find out on this dedicated page.
The Istituto di Neuroscienze represents a center of excellence for the diagnosis and treatment of ADHD in adults.
Treatment for Depression integrates many different skills and must be carried out by specially trained specialists. The treatments generally offered often do not work because the specific subtype of depression and other comorbid disorders are not considered.
At the Istituto di Neuroscienze, we offer person-centered treatment for depression based on individualized diagnosis and integrated with natural cures.
Children and Adult ADHD
Children and Adult Autism
Treatment resistant Bipolar Depression
PANDAS and behavioral immunology
Alcohol, Cocaine, Tabacco and Painkillers Addiction
Fibromyalgia and Neuropathic Pain
Obesity and Bulimia
Mild Cognitive Impairment
Traumatic Brain Disorders
Sports Neuroscience and Performance
TMS with EMRD and Mindfulness
Deep TMS with CBT
Use of Pharma-standard antioxidants and Probiotics to regulate the inflammation and the neuroplasticity in Autism and ADHD
Neuromodulation with neuropharmacology
Non-pharmacological, non-invasive, and free of side effects.
Improve cognitive abilities
Facilitate new skills learning
Repair and restore vascular damage of the brain
La terapia di Neuromodulazione è un insieme di tecniche diagnostiche e terapeutiche che utilizzano stimoli fisici, magnetici, elettrici e luminosi che agiscono promuovendo la Neurogenesi, ovvero il processo di formazione di nuove cellule nervose e in alcuni casi promuovono anche la reazione antiinfiammatoria e cicatriziale delle cellule gliali di sostegno.
Neuromodulation therapies use physical, magnetic, electrical and light stimuli that act by promoting Neurogenesis, or the process of formation of new nerve cells (neurons), increasing the neuronal plasticity and the creation of new connections (synapses) between them. In some cases, they also promote the anti-inflammatory and anti-scarring reaction of the supporting glial cells.
Neuromodulation Therapies include:
― Repetitive Transcranial Magnetic Stimulation (rTMS);
― Transcranial Magnetic Stimulation Theta-Burst (TBS);
― Deep Transcranial Magnetic Stimulation (Deep TMS);
― Transcranial Direct Current Stimulation (tDCS);
― Photo-Bio-Modulation (PBM);
― Vagus Nerve Stimulation (VNS);
― Light Therapy;
― Pulsating Electrostatic Field Therapy (PESF).
Neuromodulation Therapies represent a significant advance in the direction of Personalised Care.
Therapeutic areas of Neuromodulation Therapies
Neuromodulation Therapies offered by the Istituto di Neuroscienze can be applied effectively ― as off-label but scientifically validated therapies ― in a broad spectrum of neuropsychiatric areas and on different types of patients:
― Drug-Resistant patients;
― Patients with residual symptoms;
― Patients with cognitive symptoms;
― ECT candidates or ECT resistant patients;
― Patients with Mood Disorders (Depression, Bipolar Disorder);
― Reproductive Psychiatry patients (pregnant women);
― Post-partum Depression;
― Patients undergoing assisted fertilization;
― Depression associated with metabolic disorders;
― Depression for cases where medications should be avoided (liver / kidney failure);
― Seasonal Depression;
― Autism - reduction of repetitive behaviors and improvement of communication;
― Psychosis - reduction of hallucinations, reduction of negative symptoms;
― Obsessive Compulsive Disorder and OCD Spectrum Disorders (Trichotillomania, Tics);
― Behavioral addictions (Gambling, Internet, Pornography);
― Substance Use Disorders (Cocaine, Alcohol, THC);
― Cognitive rehabilitation;
― Post-stroke rehabilitation or head trauma;
― Pain, including headaches and fibromyalgia;
― Parkinson's Disease;
― Tinnitus (Tinnitus).
In Weight and Nutrition Disorders:
― Carbohydrate Craving;
― Obesity and Binge Eating;
― Eating Disorders.
Customized and Innovative Treatment Solutions
Precision Diagnosis for Personalized Care
Genetics of drug response;
Multidisciplinary evaluation with Immunologist, Neurologist, Rheumatologist and other specialists, depending on the cases.
Neuromodulation Therapy, Pharmacological Therapy, Psychotherapies, Pharma-Standard Supplements, Natural Cures, Mindfulness, and anything else that has been scientifically documented effective.
The possibility of consulting international experts, thanks to the collaboration with the most important specialized centers in the world.
Tele Medicine: remote psychiatric visits and psychotherapy
For continuity and shortening distances: Specialist visits and psychotherapies in tele-medicine with psychometric evaluation.
Support to patients and family
Rehabilitation and skills development program for patients with ADHD and Learning Disability.
Health Authorization in the following areas: Psychiatry, Child Neuropsychiatry, Neurophysiopathology Psychology and Psychotherapy.